%0 Journal Article
%T Prognostic Clinico-Pathological Features of 99 Cases Advanced Non-Small Cell Lung Cancer¡ªEgyptian National Cancer Institute
%A Hala Aziz Shokralla
%A Mohamed Rahouma
%J Advances in Lung Cancer
%P 29-36
%@ 2169-2726
%D 2015
%I Scientific Research Publishing
%R 10.4236/alc.2015.43005
%X Background: Worldwide, lung cancer is the most commonly diagnosed cancer
and causes more deaths than any other cancer. In Egypt; it accounts for 7% of
male cancer &amp; 3% in females. It is considered to be 3<sup><span style=\"font-family:Verdana;\">rd</span></sup><span style=\"font-family:Verdana;\"> most
common cancer in Egyptian males &amp; 6</span><sup><span style=\"font-family:Verdana;\">th</span></sup><span style=\"font-family:Verdana;\"> most common of both sexes.
Materials and Methods: A total of 99 advanced non-small cell lung cancer
patients who underwent first line platinum containing chemotherapy in our
institute were included in this study. All clinical and pathological data were
collected from patient¡¯s files retrospectively between 2012-2014. Results: All
99 cases were diagnosed at late stage IIIB-IV (59 cases were IIIB).The median
age was 54 years (range: 30 - 70) with 53% of cases are ¡Ý 54 years. 71% were
males with male: female ratio of 2.4:1. All male patients were chronic smokers.
The most frequent symptom was coughing (68%). Most of the patients had primary
lung cancer in the right lung (77%). The most common histological subtype was squamous
cell carcinoma (35.4%) with 54 cases present with PS-I, the remain was PS-II.
All cases received platinum containing chemotherapy. The majority of cases experienced
a progressive disease 60.6%. The median progression free survival (PFS) was 6
months &amp; median overall survival (OS) was 18 months. We found that PS,
disease stage, pathological subtypes and response to treatment statistically
affect both median OS &amp; PFS. Age affects only OS. Conclusions: Our analysis
suggests that some of clinico-pathological factors &amp; response to first line
platinum containing regimens affect both OS &amp; PFS of advanced NSCLC. This
may be beneficial as prognostic markers and further studies were needed to aid
in identification and treatment of these patients.</span>
%K Non-Small Cell
%K Lung Cancer
%K Clinico-Pathological
%K Prognosis
%K NCI Egypt
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=62912