%0 Journal Article
%T Cell-SELEX技术在肿瘤诊治中的应用进展
%A 吕彬
%A 综述
%A 张骏
%A 杜文琪
%A 刘杰
%A 审校
%J 复旦学报(医学版)
%P 227-232
%D 2013
%R 10.3969/j.issn.16728467.2013.02.019
%X Aptamers,selectedbyaninvitroprocessknownassystematicevolutionofligandsbyexponentialenrichment(SELEX),aresinglestrandedDNAorRNAoligonucleotideswithhighselectivity,affinityandstability.Aptamersthatcanbindwholecells,especiallycancercells,aregeneratedbyamethodcalledcellSELEX.Comparedwithantibodies,aptamerspossessmanyadvantages,includingwiderangeoftargets,quickandreproduciblesynthesis,nontoxicityandlackofimmunogenicity,easyandcontrollablemodificationtofulfilltherecognitionofcancercells.Aptamersconjugatednanomaterialsgainmoreflexibilityascancercelltargetingtools.Inthisreview,wediscusstheapplicationofcell-SELEXbasedaptamersinnovelcancerbiomarkersidentification,cancerimaging,cancertherapyandenhancedtargetingwhenconjugatedwithnanomaterials.
%K aptamer
%K cell-SELEX
%K cancer
%K nanomaterials
%U http://jms.fudan.edu.cn/CN/abstract/abstract795.shtml