%0 Journal Article
%T 基因重组人生长激素和雌/孕激素治疗Turner综合征患儿疗效观察
%A 陈丽娜
%A 向承发
%J 华西医学
%P 720-722
%D 2011
%X 【】　目的　探讨基因重组人生长激素（recombinanthumangrowthhormone，rhGH）及雌/孕激素（estrogen/progestogem，E/P）治疗对Turner综合征（Turnersyndrome，TS）患儿身高及性征发育的影响。　方法　2005年1月―2009年6月四川大学华西第二医院门诊就诊TS患儿22例，12例患儿接受rhGH治疗，年龄（13.58±2.23）岁，剂量0.15U/（kg?d），睡前皮下注射，疗程4~24个月。16例年龄≥13岁、骨龄≥11岁的患儿接受E/P治疗，疗程3~30个月。　结果　rhGH治疗后患儿身高、身高的标准差积分提高，生长速率达（9.33±2.39）cm/年；E/P治疗可促进患儿乳房发育及规律月经出现。　结论　rhGH和E/P治疗对TS患儿身高增长及性征发育有明显疗效。【Abstract】　Objective　Toexplorethetherapeuticeffectsofrecombinanthumangrowthhormone(rhGH)andsexhormoneonthestatureandsexfeatureofchildrenwithTurnersyndrome(TS).　Methods　Atotalof22childrenwithTSwereselectedintheoutpatientsdepartmentofWestChinaSecondHospitalbetweenJanuary2005andJune2009.TwelvechildrenwithTStheaverageageof(13.58±2.23)yearsreceivedrhGH0.15U/(kg?d)everynightbeforesleepfor4-24months.SixteenchildrenwithTS(age≥14yearsold,boneage≥11yearsold)underwentestrogenandprogestogen(E/P)treatmentfor3-30months.　Results　TheheightandheightstandarddeviationscoreincreasedsignificantlyinchildrenwithrhGHtherapy(P<0.01).Theheightvelocitywas(9.33±2.39)cm/yearafterthetreatment.ThetreatmentofestrogenandprogestogencouldpromotethedevelopmentofbreastandestablishmenstrualcycleinchildrenwithTS.　Conclusion　rhGHandE/PcanplayasignificantroleintreatmentofTSinchildren.
%K Turner综合征
%K 重组人生长激素
%K 雌激素/孕激素
%U http://www.hxyxqk.com.cn/oa/DArticle.aspx?type=view&id=201105023