%0 Journal Article
%T 氯胺酮超前镇痛预防瑞芬太尼麻醉后急性疼痛的临床研究
%A 朱波
%A 刘凌
%J 华西医学
%P 1523-1524
%D 2010
%X 【】目的观察在腹腔镜胆囊切除术中，氯胺酮超前镇痛对瑞芬太尼麻醉后急性疼痛的影响。方法2009年10月-2010年1月，将择期行腹腔镜胆囊切除术患者90例，随机分为对照组（C组）、氯胺酮超前镇痛组（K组）、氯胺酮术毕镇痛组（K1组），每组30例。所有患者均采用瑞芬太尼复合丙泊酚静脉麻醉，K组在切皮前静脉给予氯胺酮0.5mg/kg，K1组在关腹前静脉给予氯胺酮0.5mg/kg，C组不给予任何药物。记录术毕患者麻醉恢复情况，各时间点疼痛程度。结果K组、K1组躁动发生率均明显低于C组（P<0.05）；术后2、4、8、24h，K组VAS评分及镇痛药使用率明显低于C组和K1组（P<0.05）。结论氯胺酮超前镇痛能明显降低瑞芬太尼术后疼痛，并且不增加并发症发生率。？【Abstract】ObjectiveToevaluatethepreemptiveanalgesiaofketamineonremifentanilinducedacutepostoperativepainafterlaparoscopiccholecystectomy.MethodsNintypatientsscheduledforlaparoscopiccholecystectomybetweenoctober2009toJannary2010wererandomlyassignedtothreegroups(n=30).GroupKwasadministratedwith0.5mg/kgketamineintravenouslybeforeskinincision,andGroupK1wereadministratedwith0.5mg/kgketamineintravenouslybeforeabdominalclosure,whileGroupCreceivednothing.Therecoveryandthesideeffectswererecorded,theVASattwo,four,eightand24hoursaftersurgery,andtheuseofanodynewererecorded.ResultsTheincidenceofrestlessnessinGroupsKandK1wasremarkablylowerthanthatofGroupC(P<0.05).Theanalgesiceffectstwo,four,eightand24hoursaftersurgerywereobviouslybetteringroupKthanthoseofGroupCandGroupK1(P<0.05).ConclusionKetaminecanproducepreemptiveanalgesiatorelieveremifentanil-inducedacutepain,anditwouldnotincreaseincidenceofsideeffects.
%K 氯胺酮
%K 超前镇痛
%K 瑞芬太尼
%K 急性疼痛
%U http://www.hxyxqk.com.cn/oa/DArticle.aspx?type=view&id=201008046