%0 Journal Article
%T 老年性局部晚期乳腺癌术前内分泌治疗的临床应用
%A 龙启明
%A 张剑辉
%J 华西医学
%P 975-978
%D 2011
%X 【】　目的　探讨老年性乳腺癌术前内分泌治疗效果及降期后手术优点。　方法　2004年5月－2010年12月19例老年性局部晚期乳腺癌患者，术前给予口服芳香化酶抑制剂（aromataseinhibitors，AI）2～10个月，进行疗效观察，降期后手术及术后同一有效内分泌药物继续治疗并随访，时间1～66个月。　结果　自AI治疗开始至手术时，临床完全缓解2例，部分缓解11例，稳定3例，进展3例；手术14例，另5例由于全身状况差、基础疾病严重不能耐受手术或局部进展而放弃手术，5年总生存率68%，无瘤生存率47%。　结论　术前内分泌治疗疗效可靠，不良反应轻，特别适应老年伴有内科疾病不适应化学疗法的患者，可以增加保乳手术率和手术切除率。【Abstract】　Objective　Toinvestigatetheclinicalvalueofneo-adjuvantendocrinetherapyforlocallyadvancedbreastcancerinelderlypatientsandtheadvantagesofoperationafterdown-stagingofbreastcancer.　Methods　FromMay2004toDecember2010,19patientswithlocallyadvancedbreastcancerweretreatedwithAromataseinhibitor(AI)neo-adjuvantendocrinetherapyfor2to10monthsbeforeoperation.Theclinicalefficacywasobserved.Operationwasperformedafterdown-stagingofthecancer.Aftertheoperation,patientscontinuedtakingthesameeffectivedrugandwerefollowed-upfor1to66months.　Results　FromAItreatmenttothetimeofoperation,therewere2casesofclinicalcompleteresponse,11casesofclinicalpartialresponse,3casesofstabledisease,and3casesofprogressivedisease.Atotalof14patientswereoperated,and5otherpatientscouldnothavetheoperationforbadbodyconditions,seriousbasic-diseasesorlocalprogressofthedisease.The5-yearoverallsurvivalratewas68%,andthedisease-freesurvivalratewas47%.　Conclusion　Neo-adjuvantendocrinetherapyhasareliableclinicaleffectandlowside-effects.Itisespeciallysuitableforelderlypatientsexcludedfromchemotherapybecauseofinternalmedicaldiseases.Itcanalsoincreasetherateofbreast-conservingandsurgicalexcision.
%K 老年性乳腺癌
%K 术前治疗
%K 内分泌治疗
%K 芳香化酶抑制剂
%U http://www.hxyxqk.com.cn/oa/DArticle.aspx?type=view&id=201107006