%0 Journal Article
%T 乳腺癌不同分子亚型腋窝淋巴结转移的状态及预后分析
%A 陈波
%A 薛明兴
%A 叶春梅
%A 黄自明
%A 王蓉
%A 赵松
%J 华西医学
%P 971-974
%D 2011
%X 【】　目的　探讨乳腺癌不同分子亚型腋窝淋巴结转移的状态及预后分析。　方法　对2005年1月－2007年12月收治的125例乳腺癌患者进行分子分型，对腋窝淋巴结转移状态进行分析并结合随访结果进行预后分析。　结果　LuminalA型63例，16例淋巴结转移，转移率为25.4%；LuminalB型19例，7例淋巴结转移，转移率为36.8%；HER-2过表达型26例，11例淋巴结转移，转移率为42.3%；Basal-like型17例，9例淋巴结转移，转移率为52.9%。其中LuminalA型淋巴结转移率与Basal-like型比较差异有统计学意义（P0.05）。运用χ2检验各分子亚型在肿瘤大小的差异无统计学意义（P>0.05）。经过2~5年随访，8例患者出现局部复发或远处转移，其中LuminalB型2例，HER-2过表达型5例，Basal-like型1例。8例中有3例因肝转移死亡，另5例接受治疗现仍生存。　结论　乳腺癌的分子分型可作为腋窝淋巴结转移的预测指标，HER-2过表达型和Basal-like型预后较差，将为今后制定乳腺癌个体化治疗提供重要依据。【Abstract】　Objective　Toanalyzetheaxillarylymphnodesmetastasisofvariousbreastcancermolecularsubtypesanditsprognosis.　Methods　Molecularsubtypesof125casesofoperablebreastcancerdiagnosedandtreatedbetweenJanuary2005andDecember2007werecategorized,andtheaxillarylymphnodesmetastasisofthesetypeswasanalyzed.Atthesametime,weanalyzeditsprognosisstatuswiththeresultsofthefollow-up.　Results　Amongthe125cases,therewere63luminalAcasesinwhich16(25.4%)werefoundtobeaxillarylymphnodesmetastasis.Amongthe19luminalBcases,therewere7(36.8%)axillarylymphnodesmetastases.Therewere11cases(42.3%)ofaxillarylymphnodesmetastasisinthe26casesofHER-2(+)subtype.Inthe17casesofbasal-likesubtye,9(52.9%)wereaxillarylymphnodesmetastases.Asfortheaxillarylymphnodesmetastaticrate,onlybasal-likesubtypewashigherthanluminalAsubtypewithastatisticallysignificantdifference(P0.05).Themolecularsubtypesdidnotdifferintumorsize(P>0.05)accordingtotheresultofchi-squaretest.Duringthe2to5-yearfollow-up,8ofthe125patientswerefoundtohavelocaltumorrecurrenceordistantmetastaticdisease,whichincluded2luminalBcases,5HER-2(+)subtypecases,and1basal-likesubtypecase.Inthose8patients,3diedoflivermetastasesand5survivedandarestillacceptingtreatmentnow.　Conclusions　Molecularsubtypingcanprovideimportantinformationofaxillarylymphnodesmetastaticstatus.HER-2over-expressionandbasal-likesubtypehaveapoorprognosis,whichisanimportantbasisforindividualtreatmentofbreastcancerinthefuture.
%K 乳腺肿瘤
%K 分子亚型
%K 淋巴结转移
%K 预后
%U http://www.hxyxqk.com.cn/oa/DArticle.aspx?type=view&id=201107004