%0 Journal Article
%T 干扰素治疗蕈样霉菌病的系统评价
%A 温蓬飞
%A 余佳
%A 穆潺
%A 吴泰相
%A 王琳
%J 华西医学
%P 551-555
%D 2011
%X 【】　目的　采用系统评价方法，评估干扰素（IFN）治疗蕈样霉菌病（MF）的疗效及安全性。　方法　计算机检索截止2010年5月的Cochrane协作网系统评价方法，纳入所有比较IFN与其他方法治疗MF的随机对照试验及临床对照试验进行质量评价，采用RevMan5.0.24软件进行Meta分析。　结果　共纳入6篇符合标准的已发表文献，包括142例受试者。Meta分析结果显示IFN-α单独使用对MF的疗效优于安慰剂组OR=69.36，95%CI（3.71～1296.64）及地精丹方剂OR=35.53，95%CI（1.78～710.56）；而IFN-α与胸腺肽OR=15.11，95%CI（0.71～322.61）及IFN-α+阿维A酯OR=3.10，95%CI（0.79～12.12）的临床疗效差异无统计学意义；IFN-γ联合窄谱中波紫外线（NB-UVB）治疗与单用NB-UVB的临床疗效差异无统计学意义OR=15.00，95%CI（0.46～485.32）。90%的患者出现轻度“流感样症状”的不良反应，多可缓解及消退。　结论　IFN是目前治疗MF的一线用药，疗效确切且大部分患者耐受性较好。【Abstract】　Objective　Toevaluatetheclinicalefficacyandsideeffectsofinterferon(IFN)inthetreatmentofmycosisfungoides(MF)withthemethodofsystematicreview.　Methods　AccordingtotheCochranereviewer’shandbook,alltheclinicalcontrolledtrialsinvolvingmycosisfungoidesbeingtreatedwithinterferonwereretrieved.TheCochraneCollaboration’ssoftwareRevMan5.0.24wasusedformeta-analysis.　Results　Onlysixpapersincluding142patientsmettheinclusioncriteria.Meta-analysesindicatedtheresultsasfollowsIFN-αmonotherapywasmoreeffectivethanplaceboOR=69.36,95%CI(3.71-1296.64)andatraditionalChinesemedicine(Di-jing-dan)OR=35.53,95%CI(1.78-710.56),butnosignificantdifferencewasfoundbetweenINF-αandthymicpeptideOR=15.11,95%CI(0.71-322.61),andbetweenIFN-αmonotherapyandIFN-αcombinedwithetretinatetherapyOR=3.10,95%CI(0.79-12.12);andtherewasnosignificantdifferencebetweentheefficacyofIFN-γcombinednarrowbandultravioletB(NB-UVB)therapyandthatofsingleNB-UVBtherapyOR=15.00,95%CI(0.46-485.32);Influenza-likesideeffectsoccurredto90%ofallthepatients,whichwereusuallyslightandeasytorelease.　Conclusion　Althoughtherearesomemildsideeffects,interferonissafetotreatMF.
%K 干扰素
%K 蕈样霉菌病
%K 淋巴瘤
%K T细胞
%K 对照试验
%K 系统评价
%U http://www.hxyxqk.com.cn/oa/DArticle.aspx?type=view&id=201104022