%0 Journal Article
%T PreparationandCharacterizationofCopolymerMicellesFormedbyPoly(ethyleneglycol)-PolylactideBlockCopolymersasNovelDrugCarriers
%A 姜维
%A 王运东
%A 甘泉
%A 张建铮
%A 赵秀文
%A 费维扬
%A 贝建中
%A 王身国
%J 过程工程学报
%D 2006
%X Diblockcopolymerpoly(ethyleneglycol)methylether-polylactide(MePEG-PLA)micelleswerepreparedbydialysisagainstwater.Indomethacin(IMC)asamodeldrugwasentrappedintothemicellesbydialysismethod.Thecriticalmicelleconcentration(CMC)ofthepreparedmicellesindistilledwaterinvestigatedbyfluorescencespectroscopywas0.0051mg/mLwhichislowerthanthatofcommonlowmolecularweightsurfactants.ThediametersofMePEG-PLAmicellesandIMCloadedMePEG-PLAmicellesinnumber-averagedscalemeasuredbydynamiclightscatteringwere52.4and53.7nmrespectively.TransmissionelectronmicroscopeandscanningelectronmicroscopeobservationshowedthattheappearanceofMePEG-PLAmicelleswasinasphericalshape.ThecontentofIMCincorporatedinthecoreportionofthemicelleswas18wt.%.Theeffectsofthesynthesismethodofthecopolymeronthepolydispersityofthemicellesandtheyieldofthemicellesformationwerediscussed.
%K poly(ethyleneglycol)
%K polylactide
%K blockcopolymer
%K polymermicelle
%K drugcarrier
%U http://www.jproeng.com/qikan/Cpaper/zhaiyao.asp?bsid=495