%0 Journal Article
%T A ¡°Proteoglycan Targeting Strategy¡± for the Scintigraphic Imaging and Monitoring of the Swarm Rat Chondrosarcoma Orthotopic Model
%A Caroline Peyrode
%A Fran ois Gouin
%A Aur¨¦lien Vidal
%A Philippe Auzeloux
%A Sophie Besse
%A Marie-M¨¦lanie Dauplat
%A Serge Askienazy
%A Dominique Heymann
%A Jean-Michel Chezal
%A Fran oise Redini
%A Elisabeth Miot-Noirault
%J Sarcoma
%D 2011
%I Hindawi Publishing Corporation
%R 10.1155/2011/691608
%X Our lab developed 99mTc-NTP 15-5 radiotracer as targeting proteoglycans (PGs) for the scintigraphic imaging of joint. This paper reports preclinical results of 99mTc-NTP 15-5 imaging of an orthotopic model of Swarm rat chondrosarcoma (SRC). 99mTc-NTP 15-5 imaging of SRC-bearing and sham-operated animals was performed and quantified at regular intervals after surgery and compared to bone scintigraphy and tumoural volume. Tumours were characterized by histology and PG assay. SRC exhibited a significant 99mTc-NTP 15-5 uptake at very early stage after implant (with tumour/muscle ratio of 1.61 ± 0.14), whereas no measurable tumour was evidenced. As tumour grew, mean tumour/muscle ratio was increased by 2.4, between the early and late stage of pathology. Bone scintigraphy failed to image chondrosarcoma, even at the later stage of study. 99mTc-NTP 15-5 imaging provided a suitable set of quantitative criteria for the in vivo characterization of chondrosarcoma behaviour in bone environment, useful for achieving a greater understanding of the pathology.
%U http://www.hindawi.com/journals/srcm/2011/691608/