%0 Journal Article
%T Predictors of Impaired Glucose Regulation in Patients with Non-Alcoholic Fatty Liver Disease
%A Erifili Hatziagelaki
%A Drosos E. Karageorgopoulos
%A Athina Chounta
%A Anastasia Tsiavou
%A Matthew E. Falagas
%A George Dimitriadis
%J Experimental Diabetes Research
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/351974
%X Introduction. Many patients with non-alcoholic fatty liver disease (NAFLD) have impaired glucose regulation or type 2 diabetes mellitus (DM). We investigated characteristics of NAFLD patients associated with hyperglycemia. Methods. During a 2-hour oral glucose tolerance test (OGTT), serum glucose and insulin were measured in 152 NAFLD patients. Results. 48.7% of NAFLD patients had hyperglycemia. Age (odds ratio (OR)=1.08, 95% confidence interval (CI): 1.03–1.13), body mass index (BMI) (OR=1.12, 95% CI: 1.01–1.25), and lower high-density lipoprotein cholesterol (HDL-C) (OR=0.95, 95% CI: 0.92–0.98) proved to be independent predictors of hyperglycemia. After OGTT, 30 min insulin was lower in hyperglycemic patients (74.2¡À49.7 versus 94.5¡À53.9 μIU/ml, =0.02), while 90 min insulin (170.1¡À84.6 versus 122.9¡À97.7 μU/ml, =0.01) and 120 min insulin (164.0¡À101.2 versus 85.3¡À61.9 μIU/ml, <0.01) were higher. Conclusions. NAFLD patients with higher BMI, lower HDL-C, or older age were more likely to have impaired glucose metabolism. An OGTT could be of value for early diagnosis of DM among this population.
%U http://www.hindawi.com/journals/edr/2012/351974/