%0 Journal Article
%T Common Variants of Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes and Related Traits in Indians
%A Ganesh Chauhan
%A Ismeet Kaur
%A Rubina Tabassum
%A Om Prakash Dwivedi
%A Saurabh Ghosh
%A Nikhil Tandon
%A Dwaipayan Bharadwaj
%J Experimental Diabetes Research
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/960318
%X Hyperhomocysteinemia, a risk factor for cardiovascular disorder, obesity, and type 2 diabetes, is prevalent among Indians who are at high risk of these metabolic disorders. We evaluated association of common variants of genes involved in homocysteine metabolism or its levels with type 2 diabetes, obesity, and related traits in North Indians. We genotyped 90 variants in initial phase (2.115 subjects) and replicated top signals in an independent sample set (2.085 subjects). The variant MTHFR-rs1801133 was the top signal for association with type 2 diabetes (OR=0.78 (95%  CI=0.67–0.92), =0.003) and was also associated with 2 h postload plasma glucose (=0.04), high-density lipoprotein cholesterol (=0.004), and total cholesterol (=0.01) in control subjects. These associations were neither replicated nor significant after meta-analysis. Studies involving a larger study population and different ethnic groups are required before ruling out the role of these important candidate genes in type 2 diabetes, obesity, and related traits.
%U http://www.hindawi.com/journals/edr/2012/960318/