%0 Journal Article
%T Synthesis and characterization of an amphiphilic chitosan bearing octyl and methoxy polyethylene
%A Guanghua Liu
%A Jianqun Gan
%A Aimin Chen
%A Qian Liu
%A Xusheng Zhao
%J Natural Science
%P 707-712
%@ 2150-4105
%D 2010
%I Scientific Research Publishing
%R 10.4236/ns.2010.27087
%X An amphiphilic N-octyl-O-methoxy poly (ethylene glycol) chitosan was successfully prepared by grafting successively octyl groups onto amino groups at chitosan¡¯s C-2 position as hydrophobic moieties and methoxy polyethylene glycol (MPEG) groups onto hydroxyl groups at C-6, C-3 as hy-drophilic ones. A certain amount of -NH2 was retained in the structure of chitosan derivatives through protection by phthalic anhydride. The chemical structures and degree of N-and O-substitution of chitosan derivatives were characterized by FTIR, 1H NMR, GPC and elemental analysis, respectively. The amphiphilic property for convenient self-assembly and the preserved -NH2 groups for progressive chemical cross-linking make the resultant Nocyl-O-MPEG chitosan soluble in water and potentially applicable in preparing stable chitosan hollow microspheres, a demanding drug-carrier in medical and pharmaceutical sciences.
%K Amphiphilic Groups
%K Chitosan Derivatives
%K Protection
%K Hollow Microsperes
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=2301