%0 Journal Article
%T Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens
%A Ahmed M. Soliman
%A Mahmoud Sedeik
%J Pharmacology & Pharmacy
%P 36-42
%@ 2157-9431
%D 2016
%I Scientific Research Publishing
%R 10.4236/pp.2016.71006
%X The pharmacokinetics and tissue residue of tylosin in broiler chickens were studied after I.V. and oral administrations in a dose of 50 mg tylosin/kg.b.wt. Tylosin was obeyed a two-compartment open model following I.V. administration at a dose of 50 mg/kg.b.wt. The disposition kinetics of tylosin following I.V. administration revealed that tylosin was highly distributed with V<sub>d(area)</sub> of 6 L/kg and eliminated with half-life (t<sub>1/2<i>¦Â</i></sub>) equal to 7.29 hours. The disposition kinetics of tylosin following oral administration revealed that the maximum blood concentration (C<sub>max</sub>) was 3.40 ¦Ìg/ml attained at (t<sub>max</sub>) of 1.08 hour. Tylosin was eliminated with half-life (t<sub>1/2<i>¦Â</i></sub>) equal to 5.78 hours. The mean systemic bioavailability of tylosin after oral administration was 90.29%. Following repeated oral administration of 50 mg tylosin base/kg.b.wt once daily for 5 consecutive days, the blood (¦Ìg/ml) and tissue (¦Ìg/g) residues of tylosin showed that liver, kidney and lung contained the highest tylosin residues and completely disappeared from those tissues at 6 days after the last oral dose. Chickens should not be slaughtered for human consumption within the treatment and 6 days after the last oral administrations of tylosin.
%K Pharmacokinetics
%K Tylosin
%K Broiler Chickens
%K Bioavailability
%K Tissue Residue
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=62819