%0 Journal Article
%T Analysis of Serum Biochemical Indexes for the Diagnosis of Coronary Heart Disease in Suspected Patients
%A Hongcheng Mai
%A Zhifeng Huang
%A Tao Zhang
%J Open Access Library Journal
%V 3
%N 3
%P 1-8
%@ 2333-9721
%D 2016
%I Open Access Library
%R 10.4236/oalib.1102389
%X Background: The serum biochemical indexes are classic detection in clinical
practice. Methods: In this study, for avoiding the risks of serious complications,
high-cost in diagnosis of suspected coronary heart disease (CHD), the common biochemical
indexes were detected from 68 eligible patients with suspected CHD. Treadmill exercises
test (TET)-electrocardiogram (ECG) was measured during TET, and invasive examination
of coronary angiography (CAG, golden standard for CHD diagnosis) was also performed.
Results: For CAG, 48 patients were positive and 20 were negative; while for TET
38 were positive, 14 were inconclusive, and 16 were negative, respectively. Among
these biochemical indexes, the HbA1c (%) level in CAG positive patients was much
higher than that in CAG negative patients (<i>P</i> = 0.019). Furthermore, according to receiver operating characteristic (ROC) curve,
HbA1c showed effective diagnosis for CHD and its best cutoff value was 5.85% and
29 of the patients were HbA1c positive and 30 were negative. Conclusions: It was
found that HbA1c combined with TET obviously enhanced the sensitivity of examinations.
All the patients who were negative in both HbA1c and TET tests turned out to be
90% CAG negative, which meant that the combination might stand invasive examination
of CAG for CHD diagnosis. Further studies in multi-center investigation will be
expected to validate the findings.
%K Treadmill Exercise Test
%K Coronary Angiography
%K Receiver Operating Characteristic
%K Glycated Hemoglobin
%K Coronary Heart Disease
%K Low-Density Protein
%U http://www.oalib.com/paper/4654126