%0 Journal Article
%T Evolutionofneurotransmittergamma-aminobutyricacid,glutamateandtheirreceptors
%A Zhiheng GOU
%A Xiao WANG
%A Wen WANG
%J 动物学研究
%P 75-81
%D 2012
%R 10.3724/SP.J.1141.2012.E05-06E75
%X Gamma-aminobutyricacid(GABA)andglutamatearetwoimportantaminoacidneurotransmitterswidelypresentinthenervoussystemsofmammals,insects,roundworm,andplatyhelminths,whiletheirreceptorsarequitediversifiedacrossdifferentanimalphyla.However,theevolutionarymechanismsbetweenthetwoconservedneurotransmittersandtheirdiversifiedreceptorsremainelusive,andantagonisticinteractionsbetweenGABAandglutamatesignaltransductionsystems,inparticular,havebeguntoattractsignificantattention.Inthisreview,wesummarizetheextantresultsontheoriginandevolutionofGABAandglutamate,aswellastheirreceptors,andanalyzepossibleevolutionaryprocessesandphylogeneticrelationshipsofvariousGABAsandglutamatereceptors.WefurtherdiscusstheevolutionaryhistoryofExcitatory/NeutralAminoAcidTransporter(EAAT),atransportprotein,whichplaysanimportantroleintheGABA-glutamate“yinandyang”balancedregulation.Finally,basedoncurrentadvances,weproposeseveralpotentialdirectionsoffutureresearch.
%K Gamma-aminobutyricacid
%K Glutamate
%K Neurotransmitter
%K Receptor
%K Evolution
%K Yinandyangregulation
%U http://www.zoores.ac.cn/CN/abstract/abstract3261.shtml