%0 Journal Article
%T InvolvementofXZFP36L1,anRNA-bindingprotein,inXenopusneuraldevelopment
%A Yingjie XIA
%A Shuhua ZHAO
%A Bingyu MAO
%J 动物学研究
%P 82-88
%D 2012
%R 10.3724/SP.J.1141.2012.E05-06E82
%X XenopusZFP36L1(zincfingerprotein36,C3Htype-like1)belongstotheZFP36familyofRNA-bindingproteins,whichcontainstwocharacteristictandemCCCH-typezinc-fingerdomains.TheZFP36proteinscanbindAU-richelementsin3'untranslatedregionsoftargetmRNAsandpromotetheirturnover.However,theexpressionandroleofZFP36genesduringneuraldevelopmentinXenopusembryosremainslargelyunknown.ThepresentstudyshowedthatXenopusZFP36L1wasexpressedatthedorsalpartoftheforebrain,forebrain-midbrainboundary,andmidbrain-hindbrainboundaryfromlateneurulastagestotadpolestagesofembryonicdevelopment.OverexpressionofXZFP36L1inXenopusembryosinhibitedneuralinductionanddifferentiation,leadingtosevereneuraltubedefects.ThefunctionofXZP36L1requiresbothitszincfingerandCterminaldomains,whichalsoaffectitssubcellularlocalization.TheseresultssuggestthatXZFP36L1islikelyinvolvedinneuraldevelopmentinXenopusandmightplayanimportantroleinpost-transcriptionalregulation.
%K ZFP36L1
%K RNA-bindingprotein
%K Neuraldevelopment
%K Xenopus
%K Post-transcriptionalregulation
%U http://www.zoores.ac.cn/CN/abstract/abstract3262.shtml