%0 Journal Article
%T Basalphysiologicalparametersindomesticatedtreeshrews(Tupaiabelangerichinensis)
%A Jing WANG
%A Xin-Li XU
%A Ze-Yang DING
%A Rong-Rong MAO
%A Qi-Xin ZHOU
%A Long-Bao Lü
%A Li-Ping WANG
%A Shuang WANG
%A Chen ZHANG
%A Lin XU
%A Yue-Xiong YANG
%J 动物学研究
%D 2013
%R 10.3724/SP.J.1141.2013.E02E69
%X Establishingnon-humanprimatemodelsofhumandiseasesisanefficientwaytonarrowthelargegapbetweenbasicstudiesandtranslationalmedicine.Multifoldadvantagessuchassimplicityofbreeding,lowcostoffeedingandfacilityofoperatingmakethetreeshrewanidealnon-humanprimatemodelproxy.Additionalfeatureslikevulnerabilitytostressandspontaneousdiabeticcharacteristicsalsoindicatethatthetreeshrewcouldbeapotentialnewanimalmodelofhumandiseases.However,basalphysiologicalindexesoftreeshrew,especiallythoserelatedtohumandisease,havenotbeensystematicallyreported.Accordingly,weestablishedimportantbasalphysiologicalindexesofdomesticatedtreeshrewsincludingseveralfactors:(1)bodyweight,(2)corebodytemperatureandrhythm,(3)dietmetabolism,(4)locomotorrhythm,(5)electroencephalogram,(6)glycometabolismand(7)serumandurinaryhormonelevelandurinarycortisolrhythm.Wecomparedthephysiologicalparametersofdomesticatedtreeshrewwiththatofratsandmacaques.Resultsshowedthat(a)thecorebodytemperatureofthetreeshrewwas39.59±0.05℃,whichwashigherthanthatofratsandmacaques;(b)Comparedwithwildtreeshrews,withtwoactivitypeaks,domesticatedtreeshrewshadonlyoneactivitypeakfrom17:30to19:30;(c)Comparedwithrats,treeshrewshadpoorcarbohydratemetabolismability;and(d)Urinarycortisolrhythmindicatedthereweretwopeaksat8:00and17:00indomesticatedtreeshrews,whichmatchedactivitypeaksinwildtreeshrews.Theseresultsprovidedbasalphysiologicalindexesfordomesticatedtreeshrewsandlaidanimportantfoundationfordiabetesandstress-relateddiseasemodelsestablishedontreeshrews.
%K Domesticatedtreeshrew
%K Basalphysiologicalindexes
%K Rhythm
%K Glycometabolism
%K Stress-relatedhormone
%U http://www.zoores.ac.cn/CN/abstract/abstract3321.shtml