%0 Journal Article
%T Theroleofleptininstripedhamsterssubjectedtofoodrestrictionandrefeeding
%A Zhi-Jun ZHAO
%A Yong-An LIU
%A Jing-Ya XING
%A Mao-Lun ZHANG
%A Xiao-Ying NI
%A Jing CAO
%J 动物学研究
%P 262-271
%D 2014
%R 10.13918/j.issn.2095-8137.2014.4.262
%X Foodrestriction(FR)andrefeeding(Re)havebeensuggestedtoimpairbodymassregulationandtherebymakingiteasiertoregainthelostweightanddevelopover-weightwhenFRends.However,itisunclearifthisisthecaseinsmallmammalsshowingseasonalforgingbehaviors.Inthepresentstudy,energybudget,bodyfatandserumleptinlevelweremeasuredinstripedhamstersthatwereexposedtoFR-Re.Theeffectsofleptinonfoodintake,bodyfatandgenesexpressionsofseveralhypothalamusneuropeptidesweredetermined.Bodymass,fatcontentandserumleptinleveldecreasedduringFRandthenincreasedduringRe.LeptinsupplementsignificantlyattenuatedtheincreaseinfoodintakeduringRe,decreasedgenesexpressionsofneuropepetideY(NPY)andagouti-relatedprotein(AgRP)ofhypothalamusandleptinofwhiteadiposetissue(WAT).Hormone-sensitivelipase(HSL)geneexpressionofWATincreasedinleptin-treatedhamstersthatwerefedadlibitum,butdecreasedinFR-Rehamsters.ThisindicatesthattheadaptiveregulationofWATHSLgeneexpressionmaybeinvolvedinthemobilizationoffatstorageduringRe,whichpartlycontributestotheresistancetoFR-Re-inducedoverweight.LeptinmaybeinvolvedinthedownregulationsofhypothalamusorexigenicpeptidesgeneexpressionandconsequentlyplaysacrucialroleincontrollingfoodintakewhenFRends.
%K Bodymass
%K Foodrestriction
%K Hypothalamusneuropeptides
%K Leptin
%K Stripedhamster
%U http://www.zoores.ac.cn/CN/abstract/abstract3492.shtml