%0 Journal Article
%T Sexdifferencesinmorphine-inducedbehavioralsensitizationandsocialbehaviorsinICRmice
%A Bo ZHAN
%A Hong-Yuan MA
%A Jian-Li WANG
%A Chao-Bao LIU
%J 动物学研究
%P 103-108
%D 2015
%X Genderandgeneticstrainaretwoprominentvariantsthatinfluencedrugabuse.Althoughcertainsex-relatedbehavioralresponseshavebeenpreviouslycharacterizedinICRmice,littleisknownabouttheeffectsofsexonmorphine-inducedbehavioralresponsesinthisoutbredstrain.Therefore,inthisstudy,weinvestigatedthesexdifferencesofmorphine-inducedlocomotion,anxiety-likeandsocialbehaviorsinICRmice.Aftermorphineorsalineexposureforfourconsecutivedays(twicedaily),increasedlocomotion,moretimespentinthecentralarea,aswellasattenuatedrearingandself-groomingbehaviorswerefoundinmorphine-treatedfemalesinanopenfield;nodifferenceswerefoundinlocomotionandthetimespentinthecentralareabetweenmaleandfemalecontrols.Wheninteractingwiththesame-sexindividuals,femalecontrolswereengagedinmoresocialinvestigation,following,bodycontactingandself-groomingbehaviorsthancontrols;morphineexposurereducedcontactingandself-groomingbehaviorsinfemales;incontrast,theseeffectswerenotfoundinmales.TheseresultsindicatethatfemaleICRmicearemoreprosocialandaremoresusceptibletomorphineexposurethanmales.
%K Morphine
%K ICRmice
%K Locomotion
%K Socialbehavior
%U http://www.zoores.ac.cn/CN/abstract/abstract3580.shtml