%0 Journal Article
%T Energyintake,oxidativestressandantioxidantinmiceduringlactation
%A Guo-Xiao ZHENG
%A Jiang-Tao LIN
%A Wei-Hong ZHENG
%A Jing CAO
%A Zhi-Jun ZHAO
%J 动物学研究
%P 95-102
%D 2015
%X Reproductionisthehighestenergydemandperiodforsmallmammals,duringwhichbothenergyintakeandexpenditureareincreasedtocopewithelevatedenergyrequirementsofoffspringgrowthandsomaticprotection.Oxidativestresslifehistorytheoryproposedthatreactiveoxygenspecies(ROS)wereproducedindirectproportiontometabolicrate,resultinginoxidativestressanddamagetomacromolecules.Inthepresentstudy,severalmarkersofoxidativestressandantioxidantsactivitieswereexaminedinbrain,liver,kidneys,skeletalmuscleandsmallintestineinnon-lactating(Non-Lac)andlactating(Lac)KMmice.Uncouplingprotein(ucps)geneexpressionwasexaminedinbrain,liverandmuscle.Duringpeaklactation,grossenergyintakewas254%higherinLacmicethaninNon-Lacmice.LevelsofH2O2ofLacmicewere17.7%higherinbrain(P<0.05),but21.1%(P<0.01)and14.5%(P<0.05)lowerinliverandsmallintestinethanthatofNon-Lacmice.Malonadialdehyde(MDA)levelsofLacmiceweresignificantlyhigherinbrain,butlowerinliver,kidneys,muscleandsmallintestinethanthatofNon-Lacmice.Activityofglutathioneperoxidase(GSH-PX)wassignificantlydecreasedinbrainandliverintheLacgroupcomparedwiththatintheNon-Lacgroup.Totalantioxidantcapacity(T-AOC)activityofLacmicewassignificantlyhigherinmuscle,butlowerinkidneysthanNon-Lacmice.Ucp4anducp5geneexpressionofbrainwas394%and577%higherinLacmicethaninNon-Lacmice.ThesefindingssuggestthatKMmiceshowtissue-dependentchangesinbothoxidativestressandantioxidants.ActivitiesofantioxidantsmayberegulatedphysiologicallyinresponsetotheelevatedROSproductioninseveraltissuesduringpeaklactation.Regulationsofbrainucp4anducp5geneexpressionmaybeinvolvedinthepreventionofoxidativedamagetothetissue.
%K Antioxidant
%K Energyintake
%K Lactation
%K Metabolicrate
%K Oxidativestress
%K Uncouplingprotein
%U http://www.zoores.ac.cn/CN/abstract/abstract3579.shtml