%0 Journal Article
%T Genomicorganizationandevolutionofruminantlysozymecgenes
%A David M. IRWIN
%J 动物学研究
%P 1-17
%D 2015
%R 10.13918/j.issn.2095-8137.2015.1.1
%X Ruminantstomachlysozymeisalongestablishedmodelofadaptivegeneevolution.Evolutionofstomachlysozymefunctionrequiredchangesinthesiteofexpressionofthelysozymecgeneandchangesintheenzymaticpropertiesoftheenzyme.Inruminantmammals,thesechangeswereassociatedwithachangeinthesizeofthelysozymecgenefamily.Therecentreleaseofnearcompletegenomesequencesfromseveralruminantspeciesallowsamorecompleteexaminationoftheevolutionanddiversificationofthelysozymecgenefamily.Herewecharacterizethesizeofthelysozymecgenefamilyinextantruminantsanddemonstratethattheirpecoranruminantancestorhadafamilyofatleast10lysozymecgenes,whichincludedatleasttwopseudogenes.Evolutionaryanalysisoftheruminantlysozymecgenesequencesdemonstratethateachofthefourexonsofthelysozymecgenehasauniqueevolutionaryhistory,indicatingthattheyparticipatedindependentlyinconcertedevolution.Theseanalysesalsoshowthatepisodicchangesintheevolutionaryconstraintsontheproteinsequencesoccurred,withlysozymecgenesexpressedintheabomasumofthestomachofextantruminantspeciesshowingthegreatestlevelsofselectiveconstraints.
%K Lysozymec
%K Ruminants
%K Genefamily
%K Geneduplication
%K Concertedevolution
%K Mosaicevolution
%U http://www.zoores.ac.cn/CN/abstract/abstract3557.shtml