%0 Journal Article
%T Stereoselectivesynthesisofvic-halohydrinsandanunusualKnoevenagelproductfromanorganocatalyzedaldolreaction:Anon-enaminemode
%A P. B. Thorat
%A S. V. Goswami
%A V. P. Sondankar
%A S. R. Bhusare
%J ´ß»¯Ñ§±¨
%P 1093-1100
%D 2015
%R 10.1016/S1872-2067(14)60317-X
%X £¿Stereoselectivesynthesisbyanaldolreactionbetweenchloroacetoneandaldehydewasstudiedusingasynthesizedchiralorganocatalystandtriethylamine.Thereactiongave¦Á-chloro-¦Â-hydroxyketonesinexcellentyieldwithhighantiselectivityandenantioselectivity.ThechiralorganocatalystwasalsousedintheKnoevenagelreaction,whichgave¦Á-cyano-¦Â-hydroxyketonesatalowtemperatureandtheusualKnoevenagelproductatahightemperature.Bothproductswereobtainedingoodtomoderateyieldwithgoodantiselectivityinthecaseof¦Á-cyano-¦Â-hydroxyketonederivatives.
%K Aldolreaction
%K Asymmetricsynthesis
%K Chloroacetone
%K Diastereoselectivity
%K Hydroxypropanoate
%K Knoevenagelreaction
%K Pyrrolidinederivative
%U http://www.chxb.cn/CN/abstract/abstract21597.shtml