%0 Journal Article
%T Morphofunctional Characteristics of Pulmonary Surfactant System and Its Effect on Immune Cells in Influenza A (H1N1) Pathogenesis
%A A. V. Kovner
%A O. V. Potapova
%A V. A. Shkurupy
%A A. M. Shestopalov
%J Open Journal of Pathology
%P 1-7
%@ 2164-6783
%D 2016
%I Scientific Research Publishing
%R 10.4236/ojpathology.2016.61001
%X There is an annual increase of
influenza-related SARI cases in winter months. Despite the high relevance of
this problem, influenza pathogenesis and the role of surfactant system and its
SP-A (surfactant protein A) enzyme in antiviral defense remain poorly
understood. SP-A activates macrophage M1 polarization and triggers an
antiviral response due to the activation of T-cells and dendritic cells.
Therefore, surfactant system is an important element of infection protection
and a promising therapeutic target.
%K Influenza A (H1N1) Virus
%K Pulmonary Surfactant system
%K SP-A
%K M1/M2 Macrophages
%K Antiviral Defense
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=62555