%0 Journal Article
%T The Redox Imbalance and the Reduction of Contractile Protein Content in Rat Hearts Administered with L-Thyroxine and Doxorubicin
%A Agnieszka Korga
%A Jaroslaw Dudka
%A Franciszek Burdan
%A Justyna Sliwinska
%A Slawomir Mandziuk
%A Katarzyna Dawidek-Pietryka
%J Oxidative Medicine and Cellular Longevity
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/681367
%X Oxidative stress and disorders in calcium balance play a crucial role in the doxorubicin-induced cardiotoxicity. Moreover, many cardiotoxic targets of doxorubicin are regulated by iodothyronine hormones. The aim of the study was to evaluate effects of tetraiodothyronine (0.2, 2 mg/L) on oxidative stress in the cardiac muscle as well as contractility and cardiomyocyte damage markers in rats receiving doxorubicin (1.5 mg/kg) once a week for ten weeks. Doxorubicin was administered alone (DOX) or together with a lower (0.2T4
%U http://www.hindawi.com/journals/oximed/2012/681367/