%0 Journal Article
%T Tirapazamine-Doxorubicin Interaction Referring to Heart Oxidative Stress and Ca2+ Balance Protein Levels
%A Justyna Sliwinska
%A Jaroslaw Dudka
%A Agnieszka Korga
%A Franciszek Burdan
%A Wlodzimierz Matysiak
%A Barbara Jodlowska-Jedrych
%A Slawomir Mandziuk
%A Katarzyna Dawidek-Pietryka
%J Oxidative Medicine and Cellular Longevity
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/890826
%X Doxorubicin (DOX) causes long-term cardiomyopathy that is dependent on oxidative stress and contractility disorders. Tirapazamine (TP), an experimental adjuvant drug, passes the same red-ox transformation as DOX. The aim of the study was to evaluate an effect of tirapazamine on oxidative stress, contractile protein level, and cardiomyocyte necrosis in rats administered doxorubicin. Rats were intraperitoneally injected six times once a week with tirapazamine in two doses, 5 (5TP) and 10 mg/kg (10TP), while doxorubicin was administered in dose 1.8 mg/kg (DOX). Subsequent two groups received both drugs simultaneously (5TP
%U http://www.hindawi.com/journals/oximed/2012/890826/