%0 Journal Article
%T Hepatoprotective and Antioxidative Activities of Cornus officinalis against Acetaminophen-Induced Hepatotoxicity in Mice
%A Nam-Hun Lee
%A Chang-Seob Seo
%A Ho-young Lee
%A Da-Young Jung
%A Jun-Kyung Lee
%A Jin-Ah Lee
%A Kye Yong Song
%A Hyeun-kyoo Shin
%A Mee-Young Lee
%A Young Bae Seo
%A Hokyoung Kim
%A Hyekyung Ha
%J Evidence-Based Complementary and Alternative Medicine
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/804924
%X The fruit of Cornus officinalis Sieb. et Zucc. is commonly prescribed in Asian countries as a tonic formula. In this study, the hepatoprotective effect of ethanolic extracts of the fruit of C. officinalis (ECO) was investigated in a mouse model of acetaminophen- (APAP-) induced liver injury. Pretreatment of mice with ECO (100, 250, and 500 mg/kg for 7 days) significantly prevented the APAP (200 mg/kg) induced hepatic damage as indicated by the serum marker enzymes (AST, ALT, and LDH). Parallel to these changes, ECO treatment also prevented APAP-induced oxidative stress in the mice liver by inhibiting lipid peroxidation (MDA) and restoring the levels of antioxidant enzymes (SOD, CAT, and HO-1) and glutathione. Liver injury and collagen accumulation were assessed using histological studies by hematoxylin and eosin staining. Our results indicate that ECO can prevent hepatic injuries associated with APAP-induced hepatotoxicity by preventing or alleviating oxidative stress.
%U http://www.hindawi.com/journals/ecam/2012/804924/