%0 Journal Article
%T Inhibitory Effect of Helicteres gardneriana Ethanol Extract on Acute Inflammation
%A Juliana Oliveira de Melo
%A Laura L¨ªcia Milani de Arruda
%A Silmara Baroni
%A Maria da Concei  o Torrado Truiti
%A Silvana Martins Caparroz-Assef
%A Roberto Kenji Nakamura Cuman
%A Ciomar Aparecida Bersani-Amado
%J Evidence-Based Complementary and Alternative Medicine
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/141947
%X The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculation in situ. Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of carrageenan and the migration of polymorphonuclear cells into the inflamed pleural cavity of rats (40%). Additionally, rolling and adhesion of leukocytes and the number of leukocytes that migrated toward the perivascular space in response to the carrageenan injection were decreased by the extract (500 mg/kg). These data demonstrate the anti-inflammatory effect of the ethanol extract of Helicteres gardneriana and imply that inhibition of leukocyte-endothelial interactions is important in the extract's mechanism of action.
%U http://www.hindawi.com/journals/ecam/2012/141947/