%0 Journal Article %T Inhibitory Effect of Helicteres gardneriana Ethanol Extract on Acute Inflammation %A Juliana Oliveira de Melo %A Laura L¨ªcia Milani de Arruda %A Silmara Baroni %A Maria da Concei o Torrado Truiti %A Silvana Martins Caparroz-Assef %A Roberto Kenji Nakamura Cuman %A Ciomar Aparecida Bersani-Amado %J Evidence-Based Complementary and Alternative Medicine %D 2012 %I Hindawi Publishing Corporation %R 10.1155/2012/141947 %X The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculation in situ. Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of carrageenan and the migration of polymorphonuclear cells into the inflamed pleural cavity of rats (40%). Additionally, rolling and adhesion of leukocytes and the number of leukocytes that migrated toward the perivascular space in response to the carrageenan injection were decreased by the extract (500 mg/kg). These data demonstrate the anti-inflammatory effect of the ethanol extract of Helicteres gardneriana and imply that inhibition of leukocyte-endothelial interactions is important in the extract's mechanism of action. %U http://www.hindawi.com/journals/ecam/2012/141947/