%0 Journal Article
%T Sepsis-Related Mortality of Very Low Birth Weight Brazilian Infants: The Role of Pseudomonas aeruginosa
%A Sylvia Maria Porto Pereira
%A Maria Helena Cabral de Almeida Cardoso
%A Ana Lucia Figuexeds
%A Haroldo Mattos
%A Ronaldo Rozembaum
%A Vanessa Isidoro Ferreira
%A Maria Antonieta Portinho
%A Ana Cristina Gon alves
%A Elaine Sobral da Costa
%J International Journal of Pediatrics
%D 2009
%I Hindawi Publishing Corporation
%R 10.1155/2009/427682
%X The aim of this study is to identify risk factors for sepsis-related mortality in low birth weight (<1500 g) infants. We performed retrospective cohort study to investigate risk factors for sepsis-related mortality in all neonates birth weight <1500 g admitted to Level III neonatal intensive care unit, Brazil, April 2001/September 2004. Of the 203 cases, 71 (35%) had sepsis. Of those, gram-positive was identified in 52/87 blood cultures (59.8%), the most common Coagulase-negative Staphylococcus (31/87; 35.5%). Gram-negative was present in 29 of the 87 positive blood cultures (33.3%), with Pseudomonas aeruginosa (8/87; 9.1%), the most frequent agent. Overall 21 of 71 infants with sepsis (29.6%) died. Risk factors for sepsis-related mortality were gestational age ≤28 weeks, birth weight ≤1000 g (9.6 times more often than birth weight >1000 g), five-minute Apgar ≤7, gram-negative sepsis, mechanical ventilation (6.7 times higher than no use), and intravascular catheter. Sepsis-related mortality was due, mainly, to Pseudomonas aeruginosa; birth weight ≤1000 g and mechanical ventilation were strong sepsis-related mortality predictors.
%U http://www.hindawi.com/journals/ijped/2009/427682/