%0 Journal Article
%T Peripheral V¦Ã9V¦Ä2 T Cells Are a Novel Reservoir of Latent HIV Infection
%A Natalia Soriano-Sarabia&nbsp
%A Nancie M. Archin&nbsp
%A Rosalie Bateson&nbsp
%A Noelle P. Dahl&nbsp
%A Amanda M. Crooks&nbsp
%A JoAnn D. Kuruc&nbsp
%A Carolina Garrido&nbsp
%A David M. Margolis
%J PLOS Pathogens
%D 2015
%I Public Library of Science (PLoS)
%R 10.1371/journal.ppat.1005201
%X Eradication of HIV infection will require the identification of all cellular reservoirs that harbor latent infection. Despite low or lack of CD4 receptor expression on V¦Ä2 T cells, infection of these cells has previously been reported. We found that upregulation of the CD4 receptor may render primary V¦Ä2 cells target for HIV infection in vitro and we propose that HIV-induced immune activation may allow infection of ¦Ã¦Ä T cells in vivo. We assessed the presence of latent HIV infection by measurements of DNA and outgrowth assays within V¦Ä2 cells in 18 aviremic patients on long-standing antiretroviral therapy. In 14 patients we recovered latent but replication-competent HIV from highly purified V¦Ä2 cells demonstrating that peripheral V¦Ä2 T cells are a previously unrecognized reservoir in which latent HIV infection is unexpectedly frequent.
%U http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1005201