%0 Journal Article
%T A simple theory of protein folding kinetics
%A Vijay S. Pande
%J Quantitative Biology
%D 2010
%I arXiv
%R 10.1103/PhysRevLett.105.198101
%X We present a simple model of protein folding dynamics that captures key qualitative elements recently seen in all-atom simulations. The goals of this theory are to serve as a simple formalism for gaining deeper insight into the physical properties seen in detailed simulations as well as to serve as a model to easily compare why these simulations suggest a different kinetic mechanism than previous simple models. Specifically, we find that non-native contacts play a key role in determining the mechanism, which can shift dramatically as the energetic strength of non-native interactions is changed. For protein-like non-native interactions, our model finds that the native state is a kinetic hub, connecting the strength of relevant interactions directly to the nature of folding kinetics.
%U http://arxiv.org/abs/1007.0315v1