%0 Journal Article
%T A simplified exactly solvable model for beta-amyloid aggregation
%A Marco Zamparo
%A Antonio Trovato
%A Amos Maritan
%J Quantitative Biology
%D 2010
%I arXiv
%R 10.1103/PhysRevLett.105.108102
%X We propose an exactly solvable simplified statistical mechanical model for the thermodynamics of beta-amyloid aggregation, generalizing a well-studied model for protein folding. The monomer concentration is explicitly taken into account as well as a non trivial dependence on the microscopic degrees of freedom of the single peptide chain, both in the alpha-helix folded isolated state and in the fibrillar one. The phase diagram of the model is studied and compared to the outcome of fibril formation experiments which is qualitatively reproduced.
%U http://arxiv.org/abs/1010.4459v1