%0 Journal Article
%T Estimating the Energetic State of Malignant Cells from RNA Transcription and Protein Interaction Network Data
%A Edward A. Rietman
%A Rainer Sachs
%A Philip Hahnfeldt
%A Lynn Hlatky
%J Quantitative Biology
%D 2014
%I arXiv
%X Gene expression data, or transcription data, are surrogates for actual protein concentrations in the cells. In addition protein-protein interactions are static diagrams of all the protein-protein interactions in the cell. These interactions may consist of covalent bonding or maybe just secondary bonding such as hydrogen bonding. Given these two surrogate data types we show a technique to compute the Gibbs free energy of a cell. We apply this to yeast cell cycle and to cancer.
%U http://arxiv.org/abs/1402.5911v2