%0 Journal Article
%T Refining the Protein-Protein Interactome using Gene Expression Data
%A Sira Sriswasdi
%A Shane T. Jensen
%J Quantitative Biology
%D 2010
%I arXiv
%X Proteins interact with other proteins within biological pathways, forming connected subgraphs in the protein-protein interactome (PPI). Proteins are often involved in multiple biological pathways which complicates interpretation of interactions between proteins. Gene expression data can assist our inference since genes within a particular pathway tend to have more correlated expression patterns than genes from distinct pathways. We provide an algorithm that uses gene expression information to remove inter-pathway protein-protein interactions, thereby simplifying the structure of the protein-protein interactome. This refined topology permits easier interpretation and greater biological coherence of multiple biological pathways simultaneously.
%U http://arxiv.org/abs/1003.2811v2