%0 Journal Article
%T Simple solvation potential for coarse-grained models of proteins
%A A. Bhattacharyay
%A A. Trovato
%A F. Seno
%J Quantitative Biology
%D 2006
%I arXiv
%X We formulate a simple solvation potential based on a coarsed-grain representation of amino acids with two spheres modeling the $C_\alpha$ atom and an effective side-chain centroid. The potential relies on a new method for estimating the buried area of residues, based on counting the effective number of burying neighbours in a suitable way. This latter quantity shows a good correlation with the buried area of residues computed from all atom crystallographic structures. We check the discriminatory power of the solvation potential alone to identify the native fold of a protein from a set of decoys and show the potential to be considerably selective.
%U http://arxiv.org/abs/q-bio/0606031v1