%0 Journal Article
%T Energetic Components of Cooperative Protein Folding
%A Huseyin Kaya
%A Hue Sun Chan
%J Quantitative Biology
%D 2000
%I arXiv
%R 10.1103/PhysRevLett.85.4823
%X A new lattice protein model with a four-helix bundle ground state is analyzed by a parameter-space Monte Carlo histogram technique to evaluate the effects of an extensive variety of model potentials on folding thermodynamics. Cooperative helical formation and contact energies based on a 5-letter alphabet are found to be insufficient to satisfy calorimetric and other experimental criteria for two-state folding. Such proteinlike behaviors are predicted, however, by models with polypeptide-like local conformational restrictions and environment-dependent hydrogen bonding-like interactions.
%U http://arxiv.org/abs/cond-mat/0010167v1