%0 Journal Article %T Weighted Classification Cascades for Optimizing Discovery Significance in the HiggsML Challenge %A Lester Mackey %A Jordan Bryan %A Man Yue Mo %J Computer Science %D 2014 %I arXiv %X We introduce a minorization-maximization approach to optimizing common measures of discovery significance in high energy physics. The approach alternates between solving a weighted binary classification problem and updating class weights in a simple, closed-form manner. Moreover, an argument based on convex duality shows that an improvement in weighted classification error on any round yields a commensurate improvement in discovery significance. We complement our derivation with experimental results from the 2014 Higgs boson machine learning challenge. %U http://arxiv.org/abs/1409.2655v5