%0 Journal Article %T Isoperimetric domains in homogeneous three-manifolds and the isoperimetric constant of the Heisenberg group $\mathsf{H}^1$ %A Jih-Hsin Cheng %A Andrea Malchiodi %A Paul Yang %J Mathematics %D 2015 %I arXiv %X In this paper we prove that isoperimetric sets in three-dimensional homogeneous spaces diffeomorphic to $\mathbb{R}^3$ are topological balls. We also prove that in three-dimensional homogeneous spheres isopermetric sets are either two-spheres or symmetric genus-one tori. We then apply our first result to the three-dimensional Heisenberg group $\mathsf{H}^1$, characterizing the isoperimetric sets and constants for a family of Riemannian adapted metrics. Using $\Gamma$-convergence of the perimeter functionals, we also settle an isoperimetric conjecture in $\mathsf{H}^1$ posed by P.Pansu. %U http://arxiv.org/abs/1501.07357v2