%0 Journal Article
%T A New Experimental Polytrauma Model in Rats: Molecular Characterization of the Early Inflammatory Response
%A Sebastian Weckbach
%A Mario Perl
%A Tim Heiland
%A Sonja Braum¨¹ller
%A Philip F. Stahel
%A Michael A. Flierl
%A Anita Ignatius
%A Florian Gebhard
%A Markus Huber-Lang
%J Mediators of Inflammation
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/890816
%X Background. The molecular mechanisms of the immune response after polytrauma are highly complex and far from fully understood. In this paper, we characterize a new standardized polytrauma model in rats based on the early molecular inflammatory and apoptotic response. Methods. Male Wistar rats (250 g, 6–10/group) were anesthetized and exposed to chest trauma (ChT), closed head injury (CHI), or Tib/Fib fracture including a soft tissue trauma (Fx 
%U http://www.hindawi.com/journals/mi/2012/890816/