%0 Journal Article %T Sequential nonparametrics and semiparametrics: Theory, implementation and applications to clinical trials %A Tze Leung Lai %A Zheng Su %J Mathematics %D 2008 %I arXiv %R 10.1214/193940307000000257 %X One of Pranab K. Sen's major research areas is sequential nonparametrics and semiparametrics and their applications to clinical trials, to which he has made many important contributions. Herein we review a number of these contributions and related developments. We also describe some recent work on nonparametric and semiparametric inference and the associated computational methods in time-sequential clinical trials with survival endpoints. %U http://arxiv.org/abs/0805.2492v1