%0 Journal Article
%T Non-Stationary Forward Flux Sampling
%A Nils B. Becker
%A Rosalind J. Allen
%A Pieter Rein ten Wolde
%J Physics
%D 2012
%I arXiv
%R 10.1063/1.4704810
%X We present a new method, Non-Stationary Forward Flux Sampling, that allows efficient simulation of rare events in both stationary and non-stationary stochastic systems. The method uses stochastic branching and pruning to achieve uniform sampling of trajectories in phase space and time, leading to accurate estimates for time-dependent switching propensities and time-dependent phase space probability densities. The method is suitable for equilibrium or non-equilibrium systems, in or out of stationary state, including non-Markovian or externally driven systems. We demonstrate the validity of the technique by applying it to a one-dimensional barrier crossing problem that can be solved exactly, and show its usefulness by applying it to the time-dependent switching of a genetic toggle switch.
%U http://arxiv.org/abs/1201.3823v1