%0 Journal Article
%T Protein phase instability developed in plasma of sick patients: clinical observations and model experiments
%A Tatiana Yakhno
%J Natural Science
%P 220-227
%@ 2150-4105
%D 2010
%I Scientific Research Publishing
%R 10.4236/ns.2010.23034
%X This article discusses the causes of formation of micron-size protein structures in liquid plasma or serum of the patients with different diseases, which are accompanied by inflammatory reac-tions. Self-organizing processes in sessile dry-ing drops of natural and model biological liq-uids are used for study of possible mechanisms of development the protein phase instability in serum. There was shown that violation of opti-mal ratio between albumin and osmotic active components could lead to loss of albumin ag-gregative stability and albumin coagulation structures formation. Possible role of these structures in pathogenesis of inflammation is discussed.
%K Protein Aggregation in Serum
%K Mechanisms of Inflammation
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=1570