%0 Journal Article
%T Glioblastoma Multiforme in the Posterior Cranial Fossa in a Patient with Neurofibromatosis Type I
%A Marike L. D. Broekman
%A Roelof Risselada
%A JooYeon Engelen-Lee
%A Wim G. M. Spliet
%A Bon H. Verweij
%J Case Reports in Medicine
%D 2009
%I Hindawi Publishing Corporation
%R 10.1155/2009/757898
%X Patients with Neurofibromatosis type 1 (NF1) have an increased risk of developing neoplasms. The most common brain tumors, found in 15%–20% of NF1 patients, are hypothalamic-optic gliomas, followed by brainstem and cerebellar pilocytic astrocytomas. These tumors generally have a benign nature. NF1 patients are predisposed to a 5-fold increased incidence of high-grade astrocytomas, which are usually located in supratentorial regions of the brain. We present an NF1 patient who developed a high-grade astrocytoma in the posterior fossa and discuss possible pathophysiological mechanisms.
%U http://www.hindawi.com/crim/medicine/2009/757898/