%0 Journal Article
%T Single-molecule pulling: phenomenology and interpretation
%A Ignacio Franco
%A Mark A. Ratner
%A George C. Schatz
%J Physics
%D 2012
%I arXiv
%R 10.1002/9781118482568.ch14
%X Single-molecule pulling techniques have emerged as versatile tools for probing the noncovalent forces holding together the secondary and tertiary structure of macromolecules. They also constitute a way to study at the single-molecule level processes that are familiar from our macroscopic thermodynamic experience. In this Chapter, we summarize the essential phenomenology that is typically observed during single-molecule pulling, provide a general statistical mechanical framework for the interpretation of the equilibrium force spectroscopy and illustrate how to simulate single-molecule pulling experiments using molecular dynamics.
%U http://arxiv.org/abs/1205.5068v2