%0 Journal Article
%T Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder
%A Charity Onore
%A Judy Van de Water
%A Paul Ashwood
%J Autism Research and Treatment
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/205362
%X Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder estimated to affect 1 in 110 children in the US, yet the pathology of this disorder is not fully understood. Abnormal levels of several growth factors have been demonstrated in adults with ASD, including epidermal growth factor (EGF) and hepatocyte growth factor (HGF). Both of these growth factors serve important roles in neurodevelopment and immune function. In this study, concentrations of EGF and HGF were assessed in the plasma of 49 children with ASD aged 2¨C4 years old and 31 typically developing controls of a similar age as part of the Autism Phenome Project (APP). Levels of EGF were significantly reduced in the ASD group compared to typically developing controls ( ). There were no significant differences in HGF levels in young children with ASD and typically developing controls. EGF plays an important role in regulating neural growth, proliferation, differentiation, and migration, and reduced levels of this molecule may negatively impact neurodevelopment in young children with ASD. 1. Introduction Autism Spectrum Disorder (ASD) is a developmental disorder characterized by impairments in social interaction and communication, and the presence of restricted behaviors or interests [1]. According to the most current CDC estimate, ASD affects 1 in 110 children in the US [2], yet the pathophysiology of the disorder is largely unknown. Recently, several growth factors have been found to be dysregulated in a substantial proportion of adults with ASD [3]. In the central nervous system, growth factors can regulate the processes of neuronal growth, differentiation, and proliferation, as well as regulating neuronal survival, neuronal migration, and the formation or elimination of synapses [3]. In addition to their central function in regulating neurodevelopment, current literature has also illustrated the dual nature of many growth factors as immune modulators and highlighted their involvement in crosstalk between the immune system and the central nervous system (CNS) [4¨C7]. Many studies suggest the presence of aberrant immune activity in ASD, in the CNS [8, 9] and in the periphery [10¨C12], which may be influenced by atypical growth factor activity. Growth factor dysregulation may contribute to ASD pathology by directly affecting CNS development, and/or by augmenting immune function. Epidermal growth factor (EGF) and hepatocyte growth factor (HGF) are both involved in the growth and proliferation of several cell types, including neurons and glia of the CNS. EGF is present at high levels in the
%U http://www.hindawi.com/journals/aurt/2012/205362/