%0 Journal Article
%T Synthesis of New Mannich Products Bearing Quinoline Nucleous Using Reusable Ionic Liquid and Antitubercular Evaluation
%A Hitendra M. Patel
%J Green and Sustainable Chemistry
%P 137-144
%@ 2160-696X
%D 2015
%I Scientific Research Publishing
%R 10.4236/gsc.2015.54017
%X A series of Mannich products bearing quinoline nucleus was synthesized, characterized, and evaluated for their <i>in vitro</i> antitubercular activity against <i>Mycobacterium tuberculosis</i> H<sub>37</sub>Rv. The results showed that compounds 4b, and 4d found most active with percentage inhibition of 95, and 96, respectively, at minimum inhibitory concentration (MIC) of &gt;6.25 ¦Ìg/mL, among the synthesized compounds. Whereas, compounds 4a, 4c, 4e, and 4f exhibited considerable antitubercular activity with percentage inhibition of 71, 79, 55, and 68, respectively, at MIC of &gt;6.25 ¦Ìg/mL. The structures of synthesized compounds were elucidated by various spectroscopic tools like IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, mass and elemental analysis.
%K Antitubercular Activity
%K Green Synthesi
%K Mannich Products
%K &lt
%K i&gt
%K Mycobacterium tuberculosis&lt
%K /i&gt
%K Quinoline
%K Spectroscopic Tools
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=61104