%0 Journal Article
%T Synthesis and Characterization of Fe<sub>3</sub>O<sub>4</sub> Coated on APTES as Carriers for Morin-Anticancer Drug
%A Bassam Saif
%A Congli Wang
%A Dong Chuan
%A Shaomin Shuang
%J Journal of Biomaterials and Nanobiotechnology
%P 267-275
%@ 2158-7043
%D 2015
%I Scientific Research Publishing
%R 10.4236/jbnb.2015.64025
%X Morin (MR) is an anticancer drug present in fruits and Chinese herbs. Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles (MNPs) coated on 3-aminopropyl triethoxysilane (APTES) were synthesized (MNPs-APTES) as carriers for MR. The characterization of drug delivery system was confirmed by Fourier Transform Infrared (FTIR), Transmission Electron Microscope (TEM), X-Ray Diffraction (XRD), dynamic light scattering (DLS), and vibrating sample magnetometer (VSM). The adsorbed APTES on the magnetite surface (MNPs-APTES) was examined by FTIR. The TEM image showed that the average particle size is obtained to be about 26.7 nm for MNPs-APTES. The MR loading and release behavior of MNPs-APTES were studied and the results showed that up to 60% of the adsorbed drug was released within 4 h. In summary, the MNPs-APTES nanocarriers are based on the results, promising for targeted morin drug delivery.
%K Magnetic Nanoparticles
%K Drug Delivery
%K Flavonoid
%K Morin
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=60432