%0 Journal Article
%T 2,4-Dinitrophenol Downregulates Genes  for Diabetes and Fatty Liver in Obese Mice
%A Qian Gao
%A Jiang He
%A Tao Liao
%A Qingping Zeng
%J Journal of Biosciences and Medicines
%P 44-51
%@ 2327-509X
%D 2015
%I Scientific Research Publishing
%R 10.4236/jbm.2015.39007
%X <p class=\"MsoNormal\">
	<span lang=\"EN-US\">Whether obesity is a disease or a risk
factor of metabolic diseases including type 2 diabetes and fatty liver remains
debating, we report here that a high-fat diet (HFD) alone or HFD-combined
intramuscular injection with a high dose (1.2 mg/kg) of lipopolysaccharide
(LPS) induces mouse peripheral noninflammatory obesity. In contrast,
HFD-combined intraperitoneal injection with a low dose (0.25 mg/kg) of LPS
induces mouse visceral low-grade inflammatory obesity. While the
noninsulin-dependent diabetes mellitus (NIDDM) and nonalcoholic fatty liver
disease (NAFLD)- related genes are globally upregulated in HFD + low-dose LPS
mice, NIDDM and NAFLD genes are not extensively upregulated in HFD + high-dose
LPS mice. The mitochondrial uncoupler 2,4-dini- trophenol (DNP) in the dosage
of 16 mg/kg was found to exert a weight-reducing effect in obese mice by
compromising NF-¦ĘB-primed inflammatory responses, thereby down regulating NIDDM
and NAFLD genes. Conclusively, mouse visceral low-grade inflammatory obesity
that predisposes NIDDM and NAFLD can be ameliorated by DNP via anti-inflammation.</span>
</p>
%K Obesity
%K Metabolic Disease
%K Low-Grade Inflammation
%K 2
%K 4-Dinitrophenol
%K Anti-Inflammation
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=59675