%0 Journal Article %T The Significance of Procalcitonin and C-Reactive Protein in Diagnostic Tests for Respiratory Adenovirus Infections in Children %A Wolfgang Kunze %A Thorsten Klemm %A Jan-Peter Streidl %J Open Access Library Journal %V 2 %N 8 %P 1-8 %@ 2333-9721 %D 2015 %I Open Access Library %R 10.4236/oalib.1101717 %X Background: This study aims to answer the question if procalcitonin tests allow distinguishing bacterial from AdV infections in cases in which acute phase values are significantly elevated. Methods: 40 patients of infant and toddler age were divided into two patient groups (n = 23) and (n = 17) for comparison based on PCT 0.5 ¦Ìg/L. AdV was determined by polymerase-chain-reaction. Results: The PCT value in Group 1 is 0.21 ¡À 0.12 ¦Ìg/L, median 0.2, and 1.56 ¡À 1.07 ¦Ìg/L, median 1.3 (p = 0.0001) in Group 2. At a cut-off value of <0.5 ¦Ìg/L, C-reactive protein, leucocytes, age, fever temperature, and the duration of fever did not differ significantly. This conclusion also applies to a PCT value to <0.9 ¦Ìg/L. Conclusions: In AdV infections, CRP values of >40 mg/L are observed in more than 80% of patients. A clinically relevant conclusion of our findings is that independent of CRP levels antibiotic therapy is not indicated up to PCT levels of 0.5 ¦Ìg/l. %K Adenovirus %K Respiratory Infection %K Procalcitonin %K C-Reactive Protein %K Antibiotics %K Children %U http://www.oalib.com/paper/3148005