%0 Journal Article
%T Evaluation of Antioxidant and Anti-Inflammatory Effect of <i>Rhododendron brachycarpum</i> Extract Used in Skin Care Product by <i>in Vitro</i> and <i>in Vivo</i> Test
%A Amal Kumar Ghimeray
%A Ha Youn Lee
%A Young Hoon Kim
%A Eun Kyung Ryu
%A Moon Sik Chang
%J Technology and Investment
%P 105-111
%@ 2150-4067
%D 2015
%I Scientific Research Publishing
%R 10.4236/ti.2015.62011
%X In this study, we aimed to observe the cytotoxicity, antioxidant and anti-inflammatory activity of <span style=\"white-space:nowrap;\"><i></i></span><i>Rhododendron brachycarpum<span style=\"white-space:nowrap;\"></span></i> extract (RbE) in RAW 264.7 macrophage cell <span style=\"white-space:nowrap;\"><i></i></span><i>in vitro<span style=\"white-space:nowrap;\"></span></i> and the anti-inflammatory or soothing effect of RbE formulated cream (Multicalm-RHTM) on experimentally induced acute irritated skin in healthy subjects in vivo. In vitro study revealed that RbE significantly inhibited NO and ROS generation in a dose dependent manner without cytotoxicity. In clinical test, Multicalm-RHTM cream siginificantly reduced the SLS-enduced erythema after D5 compared to that of placebo. Overall, it can be concluded that the RbE is a non-cytotoxic, antioxidant and anti-irritant agent which can be used as a potent functional ingredient in cosmetics. Likewise, the <span style=\"white-space:nowrap;\"><i></i></span><i>in vivo<span style=\"white-space:nowrap;\"></span></i> clinical study shows that Multicalm-RHTM cream which contains 3% RbE can be used as an effective skin soothing agent.
%K Antioxidant
%K Anti-Inflammatory
%K Cytotoxic
%K &lt
%K i&gt
%K Rhododendron brachycarpum&lt
%K /i&gt
%K Cosmetics
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=56035