%0 Journal Article
%T Catalyst Free Synthesis of Pyridine-2,6-bis(2-bromo-propane-1,3-dione) and Pyrdine-2,6-bis(<i>N</i>-arylthiazoline-2-thiones)
%A Korany A. Ali
%A Mohamed A. Elsayed
%A Eman Ali Ragab
%J Green and Sustainable Chemistry
%P 39-45
%@ 2160-696X
%D 2015
%I Scientific Research Publishing
%R 10.4236/gsc.2015.51006
%X We have described herein a catalyst-free preparation method of pyridine-2,6-bis(N-alkylthiazoline-2-thiones) (4a-i) by the reaction of primary amines, CS<sub>2</sub>, and pyridine-2,6-bis(2-bromo-1,3- dicarbonyl) derivatives (2a-c) in water. Also, we have described a catalyst free, green chemistry protocols to monobromination of pyridine-2,6-bis(2-bromo-1,3-dicarbonyl) derivatives with high yield, using NBS as a brominating agent, that led to eco-friendly isolation and purification proce-dures. Furthermore, we have studied the reactivity of pyridine-2,6-bis(2-bromo-1-methyl-pro- pane-1,3-dione) (2a) towards thiourea to afford 2,6-bis(5-benzoyl-2-aminothiazol-4-yl)pyridine (9).
%K N-Alkylthiazoline-2-Thiones
%K Catalyst-Free Reactions
%K Monobromination
%K 2
%K 6-Disubstituted Pyridine
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53965